IB10 sphingotest® DPP3
IB10 sphingotest® DPP3 (Human Dipeptidyl Peptidase 3), is an ubiquitously expressed and highly conserved enzyme. DPP3 cleaves various bioactive peptides, such as angiotensin II, enkephalins. The most prominent substrate of DPP3 is angiotensin II, the central effector of the renin–angiotensin system (RAS), implicating extracellular DPP3 in the regulation of the RAS. RAS is activated in cardiovascular diseases, sepsis and septic shock and angiotensin II, in particular, has been shown to modulate many cardiovascular functions including the control of blood pressure and cardiac remodeling.